病態・病理的な研究の情報

COVID-19 の病態に関する研究

 ● Endothelial cell infection and endotheliitis in COVID-19.
  Lancet. 395,10234, 1417-1418.
  … SARS-CoV-2 が血管内皮細胞に感染し血管炎を引き起こすという報告
 ● Temporal dynamics in viral shedding and transmissibility of COVID-19.
  Nature Medicine https://doi.org/10.1038/s41591-020-0869-5
  … ウイルス排出が発症前後にピークをむかえるとの検討

COVID-19 の病理学的な研究

 ● Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study
  Ann Intern Med. 2020. DOI: 10.7326/M20-2003
  … 12例の剖検報告。58%にDVT。33%は肺塞栓が死因。
 ● 【プレプリント】Pulmonary post-mortem findings in a large series of COVID-19 cases from Northern Italy
  … 38例の剖検報告。33例に細小動脈にフィブリン血栓あり。
 ● Post‐mortem examination of COVID19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction
  Histopathology https://doi.org/10.1111/his.14134
  … COVID-19 の 21例の解剖報告。DAD と 肺の微小血栓などについて触れている。

免疫反応に関する研究

 ● 【プレプリント】Neutralizing antibodies correlate with protection from SARS-CoV-2 in humans during a fishery vessel outbreak with high attack rate
  medRxiv August 14, 2020.
 ● Seroprevalence of immunoglobulin M and G antibodies against SARS-CoV-2 in China
  Nature Medicine 05 June 2020
  … 中国での患者における IgM、IgG の分布・挙動の評価
 ● SARS-CoV-2 infection protects against rechallenge in rhesus macaques
  Science 20 May 2020: eabc4776 DOI: 10.1126/science.abc4776
  … マカク(猿)モデルの報告。二度目のチャレンジでは感染抑制がみられた。
 ● Immunology of COVID-19: current state of the science
  Immunity May 05, 2020DOI:https://doi.org/10.1016/j.immuni.2020.05.002
  … COVID-19 の免疫学的な事項に関する総説。
 ● 【プレプリント】Neutralizing antibody responses to SARS-CoV-2 in a COVID-19 recovered patient cohort and their implications
  … 感染者で中和抗体ができるかどうかの検討
 ● A possible role for B cells in COVID-19?: Lesson from patients with Agammaglobulinemia. https://doi.org/10.1016/j.jaci.2020.04.013
  … 抗体産生のできないアガンマグロブリネミア患者でも改善したとの報告
 ● Two X‐linked agammaglobulinemia patients develop pneumonia as COVID‐19 manifestation but recover
  PAI https://doi.org/10.1111/pai.13263
  … 抗体産生のできないアガンマグロブリネミア患者でも改善したとの報告
 ●【参考】The time course of the immune response to experimental coronavirus infection of man
   Epidemiol. Infect. (1990), 105, 435-446
  … 新型ではないコロナウイルスを投与するとどの程度抗体が維持されるかの報告
 ● Association between a Novel Human Coronavirus and Kawasaki Disease
  The Journal of Infectious Diseases, Volume 191, Issue 4, 15 February 2005, Pages 499–502, https://doi.org/10.1086/428291
  … 新型コロナウイルスと川崎病の関連について。

凝固能異常に関する研究

 ● Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia
  The Lancet Rheumatology May 07, 2020DOI:https://doi.org/10.1016/S2665-9913(20)30121-1
 ● Incidence of venous thromboembolism in hospitalized patients with COVID‐19
  The Journal of Thrombosis and Haemostasis https://doi.org/10.1111/jth.14888
 ● Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19
  NEJM May 5, 2020 DOI: 10.1056/NEJMc2013656
 ● COVID-19 and its implications for thrombosis and anticoagulation
  Blood 2020.4.27

その他の研究

 ● Hyperinflammatory shock in children during COVID-19 pandemic
  Lancet May 07, 2020DOI:https://doi.org/10.1016/S0140-6736(20)31094-1
  … 川崎病ショック症候群に近い小児症例の報告。
   感染はないが曝露歴のある患児がいる。

動物モデル

 ● 【プレプリント】Rapid adaptation of SARS-CoV-2 in BALB/c mice: Novel mouse model for vaccine efficacy

報道・解説・記事など

 ● Study Finds Nearly Everyone Who Recovers From COVID-19 Makes Coronavirus Antibodies
  NIH Director’s blog 2020.5.7
 ● New NIAID Study Examines Immune Responses in People Hospitalized with COVID-19
  NIAID now 2020.5.1
 ● What Is ‘Covid Toe’? Maybe a Strange Sign of Coronavirus Infection
  The New York Times 2020.5.1
 ● Coronavirus Causes Damaging Blood Clots From Brain to Toes
  Bloomberg 2020.5.4

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