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 治療薬の探索や臨床検査については、治療薬探索に関する情報 のページがあります。

 ● Severe Covid-19
  NEJM May 15, 2020 DOI: 10.1056/NEJMcp2009575
  … 重症 COVID-19 に対する治療についての現在のまとめ。
 ● Effectiveness of convalescent plasma therapy in severe COVID-19 patients.
  PNAS 2020 117 (17) 9490-9496; https://doi.org/10.1073/pnas.2004168117
  … 少数例での血漿療法の報告。安全性確認。治療効果検討は不十分。
 ● Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial
  Lancet May 08, 2020DOI:https://doi.org/10.1016/S0140-6736(20)31042-4
  … カレトラ、リバビリンと IFN1β併用医療を、カレトラ単剤との RCT。
 ● Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study
  Lancet Rheumatology May 07, 2020DOI:https://doi.org/10.1016/S2665-9913(20)30127-2
  … 後ろ向き観察。IL-1阻害薬 anakinra を、アメリカで人工呼吸器を用いていない


 ● 日本感染症学会 症例報告
 ● Descriptive study of COVID-19 outbreak among passengers and crew on Diamond Princess cruise ship, Yokohama Port, Japan, 20 January to 9 February 2020
  Eurosurveillance Volume 25, Issue 23, 11/Jun/2020
  … ダイヤモンドプリンセス号での症例の記述疫学
 ● Clinical characteristics of COVID-19 in 104 people with SARS-CoV-2 infection on the Diamond Princess cruise ship: a retrospective analysis
  The Lancet June 12, 2020DOI:https://doi.org/10.1016/S1473-3099(20)30482-5
  … ダイヤモンドプリンセス号での症例の後方的解析
 ● Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States
  Nature Medicine
 ● Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area
  JAMA. April 22, 2020. doi:10.1001/jama.2020.6775
   … NYC での 5700 症例の解析による患者特徴や予後についての報告。
 ● Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection.
  EClinicalMedicine Published:April 04,2020 DOI:https://doi.org/10.1016/j.eclinm.2020.100331
   … 潜伏期間中に手術となった患者のまとめ報告。
 ● Clinical Characteristics of Covid-19 in New York City
  NEJM April 17, 2020 DOI: 10.1056/NEJMc2010419
   … ニューヨーク市における症例の報告。
 ● COVID-19の臨床的特徴 〜⽇本COVID-19対策ECMOnet対応症例のまとめ〜


 ● Real-time tracking of self-reported symptoms to predict potential COVID-19
  Nat Med (2020). https://doi.org/10.1038/s41591-020-0916-2
  … 自覚症状記録アプリを用いての症状記録とPCRでの確定診断による検討。
 ● Development and Validation of a Clinical Risk Score to Predict the Occurrence of Critical Illness in Hospitalized Patients With COVID-19
  JAMA Intern Med. Published online May 12, 2020. doi:10.1001/jamainternmed.2020.2033
  … 中国575病院によるリスク予測スコアの開発。


 ● Clinically Applicable AI System for Accurate Diagnosis, Quantitative Measurements and Prognosis of COVID-19 Pneumonia Using Computed Tomography
  Cell April 29, 2020DOI:https://doi.org/10.1016/j.cell.2020.04.045
  … CT画像からAIによって予後が予測できる可能性を示した研究。
 ● Radiopaedia Reporting of COVID-19 Chest CT Findings




 ● Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study.
  Clinical Infectious Diseases, ciaa330, https://doi.org/10.1093/cid/ciaa330
 ● Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection.
  JAMA. Published online April 22, 2020. doi:10.1001/jama.2020.6771


 ● Association between a Novel Human Coronavirus and Kawasaki Disease
  The Journal of Infectious Diseases, Volume 191, Issue 4, 15 February 2005, Pages 499–502, https://doi.org/10.1086/428291
  … 新型コロナウイルスと川崎病の関連について。



 ● Genomewide Association Study of Severe Covid-19 with Respiratory Failure
  NEJM June 17, 2020 DOI: 10.1056/NEJMoa2020283
  … GWAS による重症者リスク因子の検討
 ● Mild or Moderate Covid-19
  NEJM April 24, 2020 DOI: 10.1056/NEJMcp2009249
  … 確立した重症化因子は、高齢、慢性肺疾患、心血管疾患、
 ● Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission
  Clinical Infectious Diseases, ciaa415, https://doi.org/10.1093/cid/ciaa415



 ● Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis
  The Lancet DOI:https://doi.org/10.1016/S0140-6736(20)31142-9
  … 距離、マスク、アイシールドによるコロナウイルスの予防効果の
 ● Face Masks Considerably Reduce COVID-19 Cases in Germany: A Synthetic Control Method Approach
  IZA DP No. 13319
  … ドイツにおけるマスクによる集団での防御効果のモデルによる検証


 ● Respiratory virus shedding in exhaled breath and efficacy of face masks.
  Nature Medicine (2020)
  … 呼気中のウイルス排出とマスクの効果についての検討報告。
 ● Effectiveness of Surgical and Cotton Masks in Blocking SARS–CoV-2: A Controlled Comparison in 4 Patients.
  Ann Intern Med. 2020. DOI: 10.7326/M20-1342
  … マスクによってウイルス飛散をどの程度防げるかの評価をした研究報告。
 ●【プレプリント】Assessment of N95 respirator decontamination and re-use for SARS-CoV-2
   … N95マスクの再利用・除染に関する評価。


 ● Contact Tracing Assessment of COVID-19 Transmission Dynamics in Taiwan and Risk at Different Exposure Periods Before and After Symptom Onset
  JAMA Intern Med. May 1, 2020. doi:10.1001/jamainternmed.2020.2020
  … 台湾CDC。感染リスクが発症前~発症後5日頃までが高いとの検討。
 ● Evidence Supporting Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 While Presymptomatic or Asymptomatic.
  Emerg Infect Dis. 2020 May 4;26(7). doi: 10.3201/eid2607.201595.
  … 潜伏期間および無症状者からも感染がおこることについての論考。
 ● Visualizing Speech-Generated Oral Fluid Droplets with Laser Light Scattering
  NEJM April 15, 2020 DOI: 10.1056/NEJMc2007800
  … 会話によって生じる飛沫を可視化した検討。
 ● COVID-19: What proportion are asymptomatic?
  … CEBM。無症状者の割合のまとめ。


 ● Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19
  NEJM May 1, 2020 DOI: 10.1056/NEJMoa2006923
  … 高血圧治療薬のACE-I・ARB は COVID-19 の病態に悪影響を及ぼさないとの解析。
 ● Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China.
  JAMA Cardiol. Published online April 23, 2020. doi:10.1001/jamacardio.2020.1624
 ● Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19
  NEJM May 1, 2020 DOI: 10.1056/NEJMoa2006923